Caspase recruitment domain-containing protein 16 is a protein in humans that is encoded by CARD16 gene. Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
The following CARD16 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CARD16 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA682727LA01HU | CARD16 Antibody |
Human | ELISA, IF |
CSB-PA682727LB01HU | CARD16 Antibody, HRP conjugated |
Human | ELISA |
CARD16 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP682727HU CSB-EP682727HU CSB-BP682727HU CSB-MP682727HU CSB-EP682727HU-B |
Recombinant Human Caspase recruitment domain-containing protein 16 (CARD16) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |