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Phosphatidylinositol 3-kinase regulatory subunit gamma is a protein in humans that is encoded by PIK3R3 gene. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
The following PIK3R3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PIK3R3 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA018006GA01HU | PIK3R3 Antibody |
Human,Mouse,Rat | ELISA,WB |
| CSB-PA622420 | PIK3R3 Antibody |
Human,Mouse,Rat | ELISA,IHC |
| CSB-PA159945 | PIK3R3 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA852884ESR1HU | PIK3R3 Antibody |
Human | ELISA, IHC |
| CSB-PA852884ESR2HU | PIK3R3 Antibody |
Human, Mouse | ELISA, WB, IHC |
PIK3R3 Proteins for Bos taurus (Bovine)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP018006BO CSB-EP018006BO CSB-BP018006BO CSB-MP018006BO CSB-EP018006BO-B |
Recombinant Bovine Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIK3R3 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP727043MO CSB-EP727043MO CSB-BP727043MO CSB-MP727043MO CSB-EP727043MO-B |
Recombinant Mouse Phosphatidylinositol 3-kinase regulatory subunit gamma (Pik3r3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIK3R3 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP733971RA CSB-EP733971RA CSB-BP733971RA CSB-MP733971RA CSB-EP733971RA-B |
Recombinant Rat Phosphatidylinositol 3-kinase regulatory subunit gamma (Pik3r3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIK3R3 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP852884HU CSB-EP852884HU CSB-BP852884HU CSB-MP852884HU CSB-EP852884HU-B |
Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Phosphatidylinositol 3-kinase regulatory subunit gamma is a protein in humans that is encoded by the PIK3R3 gene. PIK3R3 binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Xi Yang et al. showed that the overexpression of PIK3R3 promoted hepatic fatty acid oxidation via PIK3R3-induced expression of PPARα, thus improving the fatty liver phenotype in high-fat diet (HFD)-induced mice [1]. By contrast, hepatic PIK3R3 knockout in normal mice led to increased hepatic TG levels. Our study also showed that PIK3R3-induced expression of PPARα was dependent on HNF4α. The novel PIK3R3-HNF4α-PPARα signaling axis plays a significant role in hepatic lipid metabolism. As the activation of PIK3R3 decreased hepatosteatosis, PIK3R3 can be considered a promising novel target for developing NAFLD and metabolic syndrome therapies.
[1] Xi Yang, Yinjia Fu, et al. PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis [J]. Experimental & Molecular Medicine volume 50, pagee431(2018).
