Protein kinase C theta type is a protein in humans that is encoded by PRKCQ gene. Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1.
The following PRKCQ reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PRKCQ Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA160849 | Phospho-PRKCQ (Ser695) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA075054 | Phospho-PRKCQ (Ser676) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA798681 | PRKCQ (Ab-676) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA443202 | PRKCQ (Ab-695) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA593320 | PRKCQ Antibody |
Human | ELISA,IHC |
CSB-PA030269 | Phospho-PRKCQ (S676) Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA030270 | Phospho-PRKCQ (T538) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA030271 | Phospho-PRKCQ (S695) Antibody |
Human | WB, IHC, ELISA |
CSB-PA030272 | PRKCQ Antibody |
Human | IHC, ELISA |
CSB-PA030273 | PRKCQ Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA030274 | PRKCQ Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-RA978159A0HU | PRKCQ Recombinant Monoclonal Antibody |
Human, Mouse | ELISA, WB |
PRKCQ Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP894347RA CSB-EP894347RA CSB-BP894347RA CSB-MP894347RA CSB-EP894347RA-B |
Recombinant Rat Protein kinase C theta type (Prkcq) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |