Ribosomal protein S6 kinase alpha-3 is a protein in humans that is encoded by RPS6KA3 gene. Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes.
The following RPS6KA3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
RPS6KA3 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA020466LA01HU | RPS6KA3 Antibody |
Human, Rat | ELISA, WB, IHC |
CSB-PA020466LB01HU | RPS6KA3 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA020466LD01HU | RPS6KA3 Antibody, Biotin conjugated |
Human | ELISA |
RPS6KA3 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP020466MO CSB-EP020466MO CSB-BP020466MO CSB-MP020466MO CSB-EP020466MO-B |
Recombinant Mouse Ribosomal protein S6 kinase alpha-3 (Rps6ka3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RPS6KA3 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP020466HU CSB-EP020466HU CSB-BP020466HU CSB-MP020466HU CSB-EP020466HU-B |
Recombinant Human Ribosomal protein S6 kinase alpha-3 (RPS6KA3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |